| REVIEW ARTICLE |
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| Year : 2022 | Volume
: 4
| Issue : 1 | Page : 20 |
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Case report and literature review of epithelial downgrowth post-penetrating keratoplasty
Samyuktha Melachuri1, Shane Seipel2, Jennifer Li2, James D Brandt2, Mark J Mannis2
1 Department of Ophthalmology, University of Pittsburgh Medical Eye Center, Pittsburgh, Pennsylvania, USA
2 Department of Ophthalmology, University of California, Davis Eye Center, Sacramento, California, USA
Correspondence Address:
Mark J Mannis
Department of Ophthalmology, University of California, Davis Eye Center, Sacramento, California
USA
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/pajo.pajo_9_22
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Epithelial downgrowth (ED) after penetrating keratoplasty (PK) is a rare but troublesome complication, often leading to vision loss. We present a case of refractory ED and review of the literature on ED after keratoplasty. Case presentation and literature review was the study design. Intracameral 5-fluorouracil at the time of wound revision and placement of a tube implant for glaucoma control were successful in securing the closure of a fistulous wound after multiple transplant surgeries. In this case, the successful management of ED after PK was achieved with meticulous wound closure, adequate pressure control, and the mitigation of ED with chemoablation of the proliferating epithelial cells. More advanced cases may require repeated injections of antiproliferative medication, cryotherapy, or surgical excision of involved tissues.
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