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Year : 2017  |  Volume : 16  |  Issue : 4  |  Page : 103-109

Non-Specific Orbital Inflammation and Sclerosing Variant

1 Department of Ophthalmology, Nova Southeastern University, South Miami, Florida, USA
2 Cedars-Sinai Medical Center, Los Angeles, California, USA
3 Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsyl-vania, USA
4 Division of Clinical & Translational Research, Larkin Community Hospital, South Miami, Florida, USA
5 Department of Ophthalmology, Nova Southeastern University, South Miami, Florida, USA; Oculoplastics Institute, Bucharest, Romania

Correspondence Address:
DO Moises Enghelberg
Nova Southeastern University, Coral Gables, FL8585 SW 124th Ave, Miami, FL 33183
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Source of Support: None, Conflict of Interest: None

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This systematic review of biopsy proven cases of non specific orbital inflammation and sclerosing variant from 2010-2016 attempts to elucidate new findings regarding the demographic profile of the diseases. Discussion of histopathology is emphasized, as to describe the most common presenting features of non-specific orbital inflammation as well as to discuss its molecular profile. This review also discusses the therapeutic approach and discusses the “steroids vs. biopsy first” controversy regarding non-specific orbital inflammation. The incidence of IgG4 and its relationship to non-specific orbital inflammation is also discussed.

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