| ARTICLE |
|
| Year : 2015 | Volume
: 14
| Issue : 4 | Page : 108-109 |
|
|
High-resolution adaptive optics imaging complements standard spectral domain optical coherent tomography in retinal diseases with micro-structural details
Gibran Syed Gibran Syed Khurshid1, Sasha Strul2, Adam Boretsky3, Massoud Motamedi4, Praveena Gupta3
1 Department of Ophthalmology, University of Florida, Gainesville, Florida
2 Department of Ophthalmology, University of Florida, Gainesville, Florida, USA
3 Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, USA
4 Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch; Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas, USA
Correspondence Address:
MD Sasha Strul
Department of Ophthalmology University of Florida 2000 SW Archer Road Gainesville, FL
USA
 Source of Support: None, Conflict of Interest: None
|
|
|
Purpose: To evaluate if high-resolution adaptive optics confocal scanning laser ophthalmoscopy (AO-SLO) can be used as an adjunct complementary diagnostic tool to spectral domain optical coherent tomography (SD-OCT) in characterizing three macular diseases: cone-rod dystrophy, acute retinal pigment epitheliitis (Krill's disease), and occult macular dystrophy.
Methods: As part of a complete clinical examination, each patient was subjected to color fundus pictures, multimodal imaging scans with Heidelberg SpectralisTM and high-resolution retinal images with a custom built adaptive optics scanning laser ophthalmolscope (AO-SLO). The registered AO-SLO images were averaged to improve the signal to noise ratio and used to generate larger photoreceptor mosaics.
Results: AO-SLO mosaics for all three conditions showed distinct, characteristic disruptions of the photoreceptors in areas that corresponded to the abnormalities observed on fundus photography and SD-OCT scans.
Conclusions: AO-SLO defined fine structural changes associated with retinal pathology at the photoreceptor level that could not be achieved using standard diagnostic methods. A combination of adaptive optics scanning laser ophthalmoscopy (AO-SLO) and SD-OCT provided views of the retina with enhanced lateral and axial resolution. High-resolution, ultra-structural details of the retina may provide additional insights into the disease etiology, progression and management of patients with vision threatening macular diseases.
|
|
|
|
| [PDF]* |
|
 |
|
